Technology Reactive Metal Electrodeposition Process for Efficient PFAS Defluorination and Mineralization This invention uses an electrochemical process where a reactive metal is deposited onto a copper electrode in solution to break PFAS bonds, converting these chemicals into harmless fluoride ions and…
Technology A Versatile and High-throughput Assay for the Directed Evolution of Reverse Transcriptases to Profile Epigenetic Modifications With NGS Engineered reverse transcriptases (RTs) to profile epigenetic modifications have numerous advantages over traditional antibody enrichment methods including: single base pair resolution, lower sample quantities needed, and lower noise and background…
Technology Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation,…
News 30 Teams Advance to Phase II of the 2024 Edward L. Kaplan, ’71, New Venture Challenge Today, the Polsky Center for Entrepreneurship and Innovation announced the 30 Phase II teams advancing in the 2024 Edward L. Kaplan, ’71, New Venture Challenge (NVC), the University of Chicago’s...
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
Technology Broadly Neutralizing Neuraminidase Antibodies for Prophylactic and Therapeutic Treatment of Influenza One of the weaknesses of current influenza vaccines is seasonable variability in efficacy, which is predominantly caused by escape mutations in the hemagglutinin (HA) antigen, the main target of the…
News Flu Antibodies Developed at UChicago Advance with Fast-Track Grant Antibodies developed at the University of Chicago, which target a wide variety of influenza strains, are being commercialized by Celdara Medical. The antibodies were patented by the Polsky Center for...
Technology A High-Throughput, Label-Free Microfluidic System For Combinatorial Droplet Generation, Storage, And Analysis A microfluidic platform consisting of a two-layer PDMS system that generates and stores combinatorial droplets, enabling high-throughput screening with an integrated label-free, image-based detection system for real-time quantification of droplet…
Technology Prophylactic Strategy For C. Difficile Infection Prevention This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering…
Technology Self-assembling Nanofibril Particles for Controlled Release of IV and SUBQ Therapeutics Clinically approved methods for the controlled release of oral therapies have demonstrated their efficacy in reducing required dosage, administration frequency, and side effects, thereby boosting patient compliance. Despite these successes,…
Technology Machine Learning-Based Prediction Of Viral Mutations From Genomic Sequences There have been significant research efforts to develop machine learning and predictive analytics based tools to predict viral evolution which remains the main obstacle in the early detection of drug-resistant…
Technology A Sensitive and High Throughput Method for the Rapid Quantification of Radiation Induced DNA Damage Current high throughput assays to quantify radiation induced DNA damage are limited by low sensitivity and cannot reliably detect radiation induced damage lower than 10Gy (J/Kg), despite the fact that…
