News Patent of the Week: In Search of a Universal Flu Vaccine University of Chicago researchers, including Patrick Wilson, PhD, professor of medicine, UChicago Biological Sciences Division, have filed a patent for a panel of antibodies that neutralize a range of influenza...
Technology Viral RNA Modification Technique To Create Attenuated Live Vaccines For Respiratory Syncytial Virus (RSV) and Other NNS RNA Viruses A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains…
Technology A Novel Class of Antibodies For The Development Of Universal Influenza Vaccines Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin…
Technology Q11: a Highly Homogeneous Multivalent and Single-component Vaccine Adjuvating Platform There is a limited choice in clinically approved adjuvants for vaccine development. Current solutions are themselves immunogenic, causing injection site swelling and reactions. The inventors developed a 15 amino acid…
Technology Fast Flux Control of High-Q 3D Multimode Cavities 3D microwave cavities are advantageous platforms for quantum computation due to their lengthy coherence times and fast control of quantum states when interfaced with superconducting qubits. Fast magnetic control of…
News Patent of the Week: Enhancing Vaccine Efficiency Researchers at the Pritzker School of Molecular Engineering at the University of Chicago developed a new platform technology for improving the efficiency of vaccines. Jeffrey Hubbell, Eugene Bell Professor in...
News Patent of the Week: Creating a Temperature-Stable Vaccine Platform Researchers have developed a novel vaccine platform with fewer side-effects and shelf-stability, which addresses the significant challenge of distributing vaccines to developing countries.
Technology Universal TaqMan-Based Detection System for RNA Quantification Reverse transcriptase quantitative PCR (qPCR) effectively quantifies coding and noncoding RNA expressions in cells and tissue samples. Among various RT-qPCR detection systems, SYBR Green-based system is most commonly used, although…
Technology A Next-Generation mRNA Vaccine Platform For Enhancing T-Cell Responses And Improving Antiviral And Antitumor Immunity Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while…
Technology Zero-burden Risk Assessment (ZeBRA) Platform for Point-in-care Universal Screening of Complex Disorders ZeBRA is a software-based platform for universal, point-of-care risk screening that uses existing EHR data to identify patients at elevated risk for complex disorders such as Alzheimer’s disease and related…
Technology Nanovaccine That Activates The NLRP3 Inflammasome & Enhances Tumor Specific Activation Of Anti-Cancer Immunity A major attention of vaccine adjuvant development has been focused on development of robust antibody-mediated protection against pathogens. However, such adjuvants have failed to elicit a robust T-cell mediated protection…
Technology Enhanced Vaccine Efficiency via an Antigen Targeting, Immune Stimulating Co-polymer Vaccine efficacy is limited due to the inability to deliver in-tact antigens to antigen presenting (APC) dendritic cells (DCs) while simultaneously activating the cells in a non-toxic fashion. Adjuvants have…
