Technology Universal TaqMan-Based Detection System for RNA Quantification Reverse transcriptase quantitative PCR (qPCR) effectively quantifies coding and noncoding RNA expressions in cells and tissue samples. Among various RT-qPCR detection systems, SYBR Green-based system is most commonly used, although…
News Patent of the Week: In Search of a Universal Flu Vaccine University of Chicago researchers, including Patrick Wilson, PhD, professor of medicine, UChicago Biological Sciences Division, have filed a patent for a panel of antibodies that neutralize a range of influenza...
News Patent of the Week: A Universal Microfluidic Culture System Microfluidic chips are useful in several applications, such as drug discovery, because of their ability to automatically replicate various cellular environments. As opposed to traditional dish-and-pipette techniques – which can...
Technology A Novel Class of Antibodies For The Development Of Universal Influenza Vaccines Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin…
News Winter Collaboratorium to Connect Students, Scientists Showcasing a Range of Innovations The winter Collaboratorium will connect innovators from UChicago Medicine, the Physical Sciences Division, and Argonne’s Chain Reaction Innovations program with University of Chicago students. The Collaboratorium provides the opportunity for...
News UChicago Spinout Pyxis Secures $152 Million Series B, Signs Licensing Agreement with Pfizer The University of Chicago spinout Pyxis Oncology has signed a worldwide licensing agreement with Pfizer after raising $152 million to further advance its portfolio of potent biologics. Pyxis in 2019...
Technology New Platform For Targeted Immunomodulation And Vaccine Development There have been significant research efforts to develop effective vaccines that elicit a strong and durable T cell response against intracellular pathogens and cancer. A popular strategy has been to…
Technology A Novel Antibody Drug Conjugate To Improve Cancer Therapy Efficacy A novel antibody-drug conjugate (ADC) with a lactate-responsive linker, enhancing therapeutic specificity by remaining stable in healthy tissues and releasing its therapeutic payload in high lactate tumor environments. Unmet need:…
News Getting a Grip “Fundamental research is what keeps me up late at night,” says Heinrich Jaeger, PhD, the William J. Friedman and Alicia Townsend Professor of Physics at the University of Chicago. One...
Technology Viral RNA Modification Technique To Create Attenuated Live Vaccines For Respiratory Syncytial Virus (RSV) and Other NNS RNA Viruses A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains…
Technology Antibody-Polymer Conjugates For Engaging T Cells To Destroy Cancer Cells An antibody linked to a polymer that connects T cells to cancer cells enabling broad cancer targeting and effective tumor cell killing without needing tumor-specific antigens The Unmet Need: Novel…
Technology RNA Editing Technology for Enhancing Tumor Immunogenicity and Immune Checkpoint Inhibitors Novel RNA editing method to generate a multitude of neoantigens in tumor cells making the cells more recognizable by T cells and enhancing the efficacy of immune checkpoint inhibitors The…
