Technology Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases The Unmet Need: Safe, effective,…
Technology PMO-Based RNA-Degrading Chimeras For Targeted Degradation Of α-Synuclein mRNA In Neurodegenerative Diseases Phosphorodiamidate morpholino oligomer (PMO)-based RNA-degrading chimeras reduce α-synuclein protein by degrading its messenger RNA preventing protein aggregation and propagation associated with neurodegenerative diseases. The Unmet Need: More potent and selective…
Technology A Computational And Therapeutic Platform For Identifying And Correcting Unproductive Splicing To Restore Gene Expression Advanced computational tools to identify faulty RNA splicing events and design of antisense oligonucleotides to restore normal protein production in genetic diseases, especially those affecting the brain The Unmet Need:…
Technology Engineered Protein G for Creating Multivalent, Bispecific Recombinant Antibody Affinity Reagents Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and lack of avidity is particularly limiting…
Technology A Biomarker Platform for Predicting Carboplatin Sensitivity and Enabling Targeted Ovarian Cancer Immunotherapy The field of oncological diagnostics and therapeutics has long sought methods to refine treatment approaches for aggressive cancers. In conditions such as advanced high-grade ovarian cancer, there is a critical…
Technology Thermonobodies: A Novel Thermostable FN3 Binding Protein Scaffold Monobodies are synthetic binding proteins based off a human fibronectin type 3 (FN3) scaffold that have demonstrated their utility in applications such as the modification of enzyme specificity and therapeutics…
Technology Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches to assay PPIs are limited by…
Technology Novel Small Molecules for the Treatment of Pulmonary Fibrosis and Asthma Airway remodeling induced by asthma and fibrosis promotes reduced responsiveness to currently available therapies. As such, there is an urgent need for the development of novel treatments that target the…
Technology Engineered Multipurpose Antibody Module Platform Traditionally, antibodies were produced using animal immunization methodologies. While this approach is still in broad use, recombinant display technologies have now assumed the leading role in producing antibody‐based affinity reagents. A…
Technology Programmable And Hyperstable Engineered Synthetic Transcriptional Repressors A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as…
Technology Point Of Care Technology For SARS-CoV-2 Detection and Neutralization SARS-CoV-2’s enters cells when the receptor binding domain (RBD) of its spike protein (S-protein) interacts with angiotensin-converting enzyme 2 (ACE2). In order to block this RBD-ACE2 interaction, clinicians need Point…
Technology Synthetic Monoclonal Antibodies For Blocking Human Growth Hormone Receptor Signaling Synthetic monoclonal antibodies using phage display to bind and block the human growth hormone receptor, potentially offering a more potent and specific treatment for conditions like acromegaly by inhibiting receptor…
