Technology Computational-Guided Spin Defect Systems This method enables predictive growth of qubit host materials without the limitations of iterative measurements. The Unmet Need: Proper characterization of qubit host substrate and in-situ defect growth Quantum sensors…
Technology Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas systems. The Unmet Need: Method to…
Technology Novel RNA Replicon Vector For Efficient Gene Delivery To The Skin A Sindbis virus-based self-amplifying RNA vector has been engineered for long-lasting, safe gene expression in skin cells, aiming to treat genetic skin disorders like recessive X-linked ichthyosis by restoring missing…
Technology Enhanced Nitrogen Vacancy Synthesis in Diamond: Minimizing Hydrogen Passivation Keywords: Electron radiation effects, Ion implantation, Spectroscopy, Chemical vapor deposition, Optical fibers, Quantum information This method mitigates hydrogen passivation of nitrogen vacancy centers (NV centers) in diamond through vacuum annealing…
Technology Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with high efficiency and minimal off-target effects…
Technology Nanomedicine Delivery Platform For Precision Targeting Of Pancreatic β-Cells A nano-scale system delivers mRNA precisely to pancreatic β-cells, targeting both Type 1 and Type 2 diabetes preserving β-cell function and enhancing treatment specificity with minimal off-target effects The Unmet…
Page About Us about us Advancing innovative ideas and technologies from the University of Chicago ecosystem to the world. The Polsky Center’s roots trace back to the University of Chicago’s longstanding commitment to...
Technology Next-Generation Minimally Invasive Optoelectronic Implants For Chronic Disease Management The platform delivers ultra-low intensity, wireless, fully implantable photostimulation for deep tissue targets (nerves, heart, diaphragm). It spatially separates light harvesting from bioelectrical stimulation, enabling minimally invasive, leadless, genetic-modification-free interventions.…
News The Polsky Center Announces the 20 Startups Selected for India Deep Tech Accelerator The Polsky Center for Entrepreneurship and Innovation today announced the 20 startups selected to join the inaugural cohort of the India Deep Tech Accelerator, a global accelerator designed to help high-potential, Indian...
News 40 Startups to Present at Midwest Deep Tech Demo Day in San Francisco The inaugural Deep Tech Demo Day in 2025, held at Pear VC in San Francisco. The Polsky Center for Entrepreneurship and Innovation today announced the 40 startups from leading Midwest...
News The Polsky Center Joins Statewide Effort to Attract NSF Quantum X-Labs Teams to Illinois The Polsky Center for Entrepreneurship and Innovation is joining the State of Illinois and quantum organizations across Chicago to provide funding, facilities, and venture-building support for teams pursuing quantum technologies through the U.S. National Science Foundation’s X-Labs initiative.
Technology Adaptive Microbial Platform For Gut Health, Biofuel, And Soil Productivity A novel biomaterial platform designed to enhance microbial modulation, featuring tunable chemical, mechanical, and optical responsiveness for applications in health, agriculture, and industry. The Unmet Need: Current clinically deployable materials…
