Technology Novel Platform for Allosterically Modifying Enzyme Specificty Fine tuning enzyme specificity is desired for industrial catalysis. Enzymes lacking structural characterization or favorable recombinant expression are not amenable to traditional directed evolution or de novo design approaches. “Monobodies”…
Technology Injectable Calcium Phosphate Amorphous Nanoparticle Pastes for Orthopedic Applications Calcium phosphates have chemical similarity to bones and teeth, and as such, these compounds are highly desired for orthopedic and dental implant applications. However, current formulations have limited bioavailability and…
Technology CAR T-Cells That Recognize Cancer-specific Glycopeptides Across Multiple Cancer Types The development of cancer immunotherapies is limited by a lack of targetable tumor antigens. Most currently targeted antigens have basal expression in healthy tissue, which results in potentially life threatening…
Technology Silicon Mesh for the Remote Modulation of Organ Electrical Activity Electric organ stimulation has shown promise in the clinic for treating aberrant neurological and cardiac activity. Problematically, this approach is limited by the high risk associated with surgical or gene…
Technology Functionalized Metal Carbides For Energy Storage The invention is a novel synthetic approach for surface modification of two-dimensional (2D) metal carbides (MXenes) using molten inorganic salts. Surface modification of MXenes have been hypothesized to affect material…
Technology Nanoparticles Containing Multiple Cleavable Prodrugs For Cancer Therapy Specially designed nanoparticles to deliver multiple cancer drugs at once, improving drug stability, targeting tumors more effectively, and reducing side effects by controlling and triggering drug release directly at the…
Technology A Method for Fast Adapting Similarity Searches Based on Variance Aware Quantization With the explosive growth of high-dimensional data, approximate methods emerge as promising solutions for searching for similar data pairs. Quantization methods have gained prominence due to their low storage costs…
Technology Layered Quantum Diamond Sensors for Selective Detection and Nanoscale Spectroscopy of Biomolecules This technology is a layered device built on a diamond substrate that uses capture agents to trap specific biological or chemical targets while maintaining excellent nitrogen vacancy (NV) spin coherence…
Technology Engineered Mutator tRNAs For Correcting Missense Genetic Defects And Inducing Cancer Cell Death Engineered tRNAs with altered anticodons and chemical modifications deliver the correct amino acid at mutated codons to restore protein function in genetic diseases or induce lethal mistranslation in cancer cells,…
Technology A Microbial Consortia That Depresses Klebsiella Pneumoniae Drug-resistant Enterobacteriaceae (particularly K. pneumoniae) are a growing cause of hospital-acquired infections, pneumonia, and antibiotic failure. Broad-spectrum antibiotics exacerbate dysbiosis and resistance, while fecal microbiota transplant lacks standardization, mechanistic clarity,…
Technology Computational-Guided Spin Defect Systems This method enables predictive growth of qubit host materials without the limitations of iterative measurements. The Unmet Need: Proper characterization of qubit host substrate and in-situ defect growth Quantum sensors…
Technology Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas systems. The Unmet Need: Method to…
