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Technology Nucleic Acid Enrichment And Sequencing Method For Detecting Off-Target Base Editing Events Inrich-seq is a new method that selectively enriches and sequences inosine-containing DNA or RNA, enabling highly sensitive, genome-wide detection of off-target effects from adenine base editing in human cells The…
Technology An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV delivery. The unmet Need: New CRISPR-systems…
Technology Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas systems. The Unmet Need: Method to…
Technology Type I Interferons For Enhancing Chimeric Antigen Receptor T-Cell Efficacy Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing…
Technology Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The…
News Alumni New Venture Challenge Selects 25 Startups for 2022 Contest The Polsky Center for Entrepreneurship and Innovation is pleased to announce the 25 startups accepted into the 2022 Alumni New Venture Challenge (ANVC), a global competition dedicated to supporting all University of...
News Eight Alumni-Led Startups to Compete in 2022 ANVC Finals The Polsky Center for Entrepreneurship and Innovation is pleased to announce the eight finalist teams that will vie for investment in the 2022 Alumni New Venture Challenge (ANVC), a global competition dedicated...
News Alumni New Venture Challenge Awards First Place to UNLISTED, a Startup Connecting Home Buyers with Off-Market Properties The winner of the Polsky Center’s 4th annual Alumni New Venture Challenge (ANVC) is a Midwest startup that helps home buyers find their dream home with a secret weapon: cookies....
News How the Alumni New Venture Challenge Helped Lead These Startups to Success Launched in 2019, the Alumni New Venture Challenge (ANVC) is the newest track of the New Venture Challenge – the top-ranked university accelerator that has been helping seed businesses for...
News Discovery Matters Alan Thomas, Director, UChicagoTech, Ellen Rudnick, Executive Director and Clinical Professor of Entrepreneurship at the Polsky Center, Keith Moffat, Deputy Provost for Research, Donald Levy, Vice President for Research and...
Team Madhav V. Rajan, MS, PhD Steven S. Wymer Dean, Chicago Booth; Distinguished Service Professor of Accounting, Chicago Booth; Chief Global Strategist, University of Chicago Steven S. Wymer Dean, Chicago Booth; Distinguished Service Professor of Accounting, Chicago Booth; Chief Global Strategist, University of Chicago