Technology A New Genetic Medicine Strategy For Treating Neurological Disorders Synaptic transmission and plasticity are fundamental to neuronal functions, and alterations of synaptic protein expression are direct causes of autism, intellectual disability (ID), and epilepsy. De novo loss-of-function (LoF) mutations…
Technology Diagnostic For Predicting Hospital-Acquired Infections And Identifying Causative Organisms The technology is a fecal microbiome metabolite profile that can predict hospital-acquired infections and identify the causative organisms. This method efficiently measures specific chemical metabolites produced by bacteria in the…
Technology AI-Based Ultrasound Analysis System For Automated Segmentation And Classification Of Adnexal Lesions AI-driven system automatically segments adnexal masses in ultrasound images, distinguishes different tissue components, and extracts key features to accurately classify lesions as benign or malignant, improving clinical diagnosis and workflow…
Technology Ergonomic Arm Board For Transradial Approach Catherization Procedures Cardiac catherization, or angiography, is a procedure used to gain access to a patient's arterial system, and is used to treat and diagnose many heart conditions. While the transfermoral (through…
Technology Novel Metabolite-Based Diagnostic Technology for Accurate Cavernous Angioma Identification and Risk Assessment Newly identified plasma metabolites linked to cavernous angioma, a neurovascular disease, using machine learning and multi-omics data to improve diagnostic precision and offer new insights for developing specific biomarkers The…
Technology OSCA: A System For Efficient Construction Of Adenovirus Vectors Adenoviruses (Ad) are a non-enveloped linear double-stranded DNA viruses with over 50 serotypes identified in humans. They have received significant attention as an in vitro and in vivo gene delivery…
Technology Computational Framework For Unraveling Single-Cell Transcriptional Dynamics Novel system using statistical topic modeling and a bursty transcriptional model to analyze spliced and unspliced RNA, revealing precise cell state transitions and dynamics in complex biological systems The Unmet…
Technology Defined Live Biotherapeutic Compositions That Restore Depleted Gut Metabolites To Improve Outcomes In Liver Disease Patients Patients with advanced liver disease, transplant recipients, and other critically ill populations frequently experience profound microbiome dysbiosis due to antibiotics and hospitalization. This dysbiosis is characterized by loss of microbial…
Technology Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase A novel platform, bacterial deaminase-enabled recoding of RNA (DECOR), utilizing an engineered bacterial adenosine deaminase to achieve programmable adenosine-to-inosine (A-to-I) editing on single-stranded RNA. The Unmet Need: Novel effector proteins…
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