Technology A Method for Fast Adapting Similarity Searches Based on Variance Aware Quantization With the explosive growth of high-dimensional data, approximate methods emerge as promising solutions for searching for similar data pairs. Quantization methods have gained prominence due to their low storage costs…
Technology Novel Metabolite-Based Diagnostic Technology for Accurate Cavernous Angioma Identification and Risk Assessment Newly identified plasma metabolites linked to cavernous angioma, a neurovascular disease, using machine learning and multi-omics data to improve diagnostic precision and offer new insights for developing specific biomarkers The…
Technology Bioadhesive Polymer for Connecting Semiconductors to Wet Tissue This method imparts bioadhesive properties onto polymeric semiconductors, which enables effective transductions of bio-signals from biological tissues to electronic devices. The Unmet Need: Conformable and stable integration of semiconductor-based biosensing…
Technology Core-shell Diamond Particle Systems for Improved Quantum Sensing The invention uses core-shell nanoparticles with a diamond core and protective shell to create quantum sensors for biological sensing. The Unmet Need: Improved sensitivity for spin qubit sensors capable of…
Technology New Class of Biocompatible and Flexible Optoelectronic Devices For Next Generation Pacemakers Electrode-based electrical stimulation underpins several clinical bioelectronic devices, including deep brain stimulators and cardiac pacemakers. Pacemaker therapy improves quality of life and reduces mortality rates. Despite significant advances, current pacemaker…
Technology Targeting TGFβ Signaling for Enhancing Cancer Radiotherapy and Immunotherapy Efficacy The method leverages a negative regulator to inhibit TGFβ signaling in myeloid cells, potentially enhancing the efficacy of radiotherapy and immunotherapy in cancer treatment by reducing immune suppression. The problem:…
Technology A Chimeric Antigen Coreceptor System For Optimized Antigen Targeting A novel chimeric antigen coreceptor system mimicking the CD4/CD8 and TCR interaction to enhance signaling for increased antigen sensitivity to treat B cell malignancies. The unmet need: Solutions for…
Technology Nanomedicine Delivery Platform For Precision Targeting Of Pancreatic β-Cells A nano-scale system delivers mRNA precisely to pancreatic β-cells, targeting both Type 1 and Type 2 diabetes preserving β-cell function and enhancing treatment specificity with minimal off-target effects The Unmet…
Technology RNA-Guided Control Of Protein Secretion And Membrane Protein Expression Innovative methods to engineer small nucleolar RNAs to target specific mRNAs to increase or decrease the secretion of desired proteins offering scalable solutions for disease treatment and advancing research capabilities.…
Technology Multihydroxy-Propane Vesicle System and Method for Topical Delivery of mRNA Groundbreaking advancement in the field of mRNA topical delivery systems, providing superior penetration, stability, and biocompatibility compared to existing solutions. It opens up new possibilities for both therapeutic and cosmetic…
Technology A Novel Antibody Drug Conjugate To Improve Cancer Therapy Efficacy A novel antibody-drug conjugate (ADC) with a lactate-responsive linker, enhancing therapeutic specificity by remaining stable in healthy tissues and releasing its therapeutic payload in high lactate tumor environments. Unmet need:…
Technology A Wearable Bioelectronic Patch For Controlling Bacterial Pathogens Without Antibiotics A wearable patch using an acidic hydrogel and low-voltage electricity to safely reduce harmful bacteria on skin. The bioelectric system sensitizes bacteria, then modulates their behavior to prevent infection without…
