Technology A Versatile and High-throughput Assay for the Directed Evolution of Reverse Transcriptases to Profile Epigenetic Modifications With NGS Engineered reverse transcriptases (RTs) to profile epigenetic modifications have numerous advantages over traditional antibody enrichment methods including: single base pair resolution, lower sample quantities needed, and lower noise and background…
Page Chuan He // RNA Modification Biology and Cancer Epigenetics Chuan He, John T. Wilson Distinguished Service Professor, Department of Chemistry, is an expert in the field of RNA modification biology and cancer epigenetics. He was the first to champion...
Technology Viral RNA Modification Technique To Create Attenuated Live Vaccines For Respiratory Syncytial Virus (RSV) and Other NNS RNA Viruses A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains…
News UChicago, Duality Teams to Pitch at 2021 Chicago Venture Summit Several teams from the University of Chicago and Duality – the world’s first accelerator focused exclusively on quantum technologies – pitched at the 2021 Chicago Venture Summit. The venture capital...
Technology New Reversible Uridine Modification Chemistry For Labeling and Functionalizing Native Nucleic Acids A chemical process that enables reversible, covalent RNA modification-highly selective for uridine enabling diverse functional group attachment, facilitating nucleic acid labeling The Unmet Need: Reversible labeling of native RNA in…
Technology Low-Input Methylation Sequencing For Profiling Epitranscriptomic Signatures And Early Colorectal Cancer Diagnosis A method that analyzes cfRNA methylation in plasma to distinguish human RNA from microbiome RNA, accurately detecting colorectal cancer through specific methylation markers even in ultralow input samples. The Unmet…
News CRISPR-Modified Skin Grafts to Treat Addiction? ‘The Opportunities Are Endless,’ Says CEO AddGraft Therapeutics has developed a novel platform that aims to effectively treat substance use disorders with genetically engineered skin grafts – a first-of-its-kind treatment with myriad applications. Developed by University of...
News UChicago’s Chuan He Recognized for Real-World Impact of Research University of Chicago researcher Chuan He has been recognized for the potential real-world impact of his work – including a method to dramatically increase crop yields and an innovative liquid...
Technology Novel Platform for Allosterically Modifying Enzyme Specificty Fine tuning enzyme specificity is desired for industrial catalysis. Enzymes lacking structural characterization or favorable recombinant expression are not amenable to traditional directed evolution or de novo design approaches. “Monobodies”…
News Esya Labs Leads Paradigm Shift in Alzheimer’s Using Novel Biomarkers and AI for Revolutionary 360° Perspective of Disease Esya Labs is developing tools for the early, precise, and cost-effective detection of neurodegenerative diseases to support drug discovery and personalized medicine efforts. In her lab at the University of Chicago, Chemistry...
News Three Teams Selected for Spring 2021 George Shultz Innovation Fund The Polsky Center for Entrepreneurship and Innovation at the University of Chicago has announced the companies selected for the 2021 spring cohort of the George Shultz Innovation Fund. The program invests...
Technology Small Molecule Inhibitors Targeting RNA Modifying Enzymes to Modulate Drug Response and Overcome Drug Resistance DNA hypomethylating agents have been widely used to treat various hematologic and non-hematologic malignancies. However, accumulating evidence has demonstrated that DNA methylation status does not correlate with clinical response to…
