Technology A Non-Hormonal Therapeutic Platform For Targeting M6A Regulators To Treat Uterine Fibroids A non-hormonal therapeutic strategy for uterine fibroids targeting the upregulated m6A regulator METTL3 employing small molecule inhibitors thereby reducing fibroid cell proliferation and increasing apoptosis. The Unmet Need: Novel…
Technology An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV delivery. The unmet Need: New CRISPR-systems…
Technology Antibody-Polymer Conjugates For Engaging T Cells To Destroy Cancer Cells An antibody linked to a polymer that connects T cells to cancer cells enabling broad cancer targeting and effective tumor cell killing without needing tumor-specific antigens The Unmet Need: Novel…
Technology Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases The Unmet Need: Safe, effective,…
Technology NeuroSight ICP: AI-Assisted, Real-Time Forecasting of Intracranial Pressure Crises NeuroSight ICP is a bedside-ready, AI-assisted forecasting system designed to predict intracranial pressure (ICP) crises roughly 30 minutes before onset using continuous neuro-monitoring data. It combines interpretable statistical modeling with…
Technology Lymphangiogenesis For Therapeutic Immunomodulation A vaccine platform that uses engineered lymphangiogenesis factors and antigens to stimulate lymphatic endothelial cells, creating strong, long-lasting immune memory or tolerance with fewer side effects than traditional vaccines The…
Technology Small Molecule Therapeutics For Inhibiting Carotid Body Hypersensitivity To Treat Sleep-Related Breathing Disorders New compounds that inhibit an enzyme to reduce hydrogen sulfide in the carotid body, helping to normalize breathing and prevent sleep apnea by targeting the underlying cause of abnormal breathing…
Technology Automated Microfluidic Platform For High-Throughput 3D Cell Culture, Dynamic Stimulation, And Single-Cell Analysis Automated microfluidic platform enabling high-throughput, precise 3D cell and organoid culture, drug screening, and single-cell analysis, allowing real-time monitoring and dynamic control of cellular environments for advanced research in cancer,…
Technology Nanoparticles Containing Multiple Cleavable Prodrugs For Cancer Therapy Specially designed nanoparticles to deliver multiple cancer drugs at once, improving drug stability, targeting tumors more effectively, and reducing side effects by controlling and triggering drug release directly at the…
Technology Oral Systemically-Bioavailable Butyrate For Treating Inflammatory Diseases Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions…
Technology A Biomarker Analysis Platform For Predicting Immunotherapy Response And Survival In Cancer Patients A method using tumor sequencing data to measure membrane-localized neoantigens, helping predict which cancer patients will benefit from immunotherapy, even those with low tumor mutational burden, improving treatment selection and…
Technology Physics-Informed Autoencoder For Non-Invasive Prediction Of Tissue Composition From MRI Data A deep learning tool that quickly and accurately estimates prostate tissue composition from MRI scans, combining physical modeling and AI to provide robust, non-invasive cancer diagnostics without needing large, labeled…
