News Eye for Opportunity, Appetite for Collaboration Few, if any, University of Chicago faculty members have as many patents, products and promising commercial endeavors in various stages of development as does Ralph Weichselbaum, MD. The D.K. Ludwig...
News Innovation Fund Advances Test for Cancer Therapy The primary treatment for breast cancer is either tumor excision followed by radiation or mastectomy with or without radiation therapy. Either course is often followed with chemotherapy. But radiation therapy...
Technology Targeting TGFβ Signaling for Enhancing Cancer Radiotherapy and Immunotherapy Efficacy The method leverages a negative regulator to inhibit TGFβ signaling in myeloid cells, potentially enhancing the efficacy of radiotherapy and immunotherapy in cancer treatment by reducing immune suppression. The problem:…
Technology Boosting Cancer Immunotherapy Or Radio-Immunotherapy For Enhanced Tumor Eradication New cancer therapy to enhance the efficacy of checkpoint inhibitor immunotherapy and radiation by blocking tumor-promoting signals from erythroid progenitor cells, which secrete artemin to advance cancer progression. This approach…
Technology IRDS: Predictive 7-gene Signature for Breast Cancer Therapy After surgical removal of breast cancer tumors, adjuvant chemotherapy and radiation therapy have an absolute survival benefit of just 5-10%. Currently approved breast cancer diagnostics do not predict patient responses…
Technology siRNA/shRNA Therapy for the Sensitization of Treatment-resistant Solid Tumors to Chemo and Radiation Therapy Adjuvant radiation therapy post-surgery remains largely ineffective, with just 5% of patients showing a survival benefit. Small molecule JAK inhibitors have shown efficacy in the clinic at treating these patients,…
Technology Small Molecule Inhibitor Boosting The Efficacy Of Therapeutic Ionizing Radiation Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is…
Technology A Gene-Modified T Cell Platform For Spatially Controlled Therapeutic Protein Delivery In Response To Radiation Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for…
Technology Amphiregulin Screening And Inhibition Methods For Reducing Metastasis And Enhancing Radiotherapy Efficacy Methods to improve radiotherapy by blocking the protein Amphiregulin (AREG), which helps tumors resist treatment and spread. Inhibiting AREG enhances anti-tumor effects and reduces metastasis, making radiotherapy more effective …
News Cultivating Partners Whether it comes to medical devices, therapeutics or pharmaceuticals, Richard Ganz brings a rich background, widespread knowledge and 30 years of experience to help University of Chicago researchers translate their...
News Giving Back to Chicago and the University Knowing that the top areas in the country for biotechnology innovation and entrepreneurship are San Francisco, San Diego and Boston-Cambridge, many of Chicago’s top researchers might be tempted to move...
News Four UChicago Projects Advance in Chicago Biomedical Consortium Accelerator The latest cohort of the Chicago Biomedical Consortium Accelerator Network (CBCAN) program includes four teams from the University of Chicago. “This is the greatest number of UChicago projects to advance...
