Technology Diagnostic Assays And Engineered Compositions For Detecting Angiotensin II Autoantibodies And Preventing Coronavirus Autoimmunity Detection and monitoring of autoantibodies against Angiotensin II in COVID-19 patients, guiding diagnosis, treatment, and vaccine design to reduce blood pressure complications and prevent harmful autoimmune responses linked to the…
Technology Engineered Cytokine-Receptor System For Enhanced Cancer And Viral Infection Treatment The technology enhances cytokine signaling and immune function, optimizing the antiviral and anti-cancer efficacy of Type III IFNs by adjusting cytokine-receptor interaction affinity and relative JAK geometry, providing an effective…
Technology Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches to assay PPIs are limited by…
Technology Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation,…
Technology Neurophysiological Biomarker for Early ALS Detection Presently, physicians rely on a costly and invasive battery of tests for diagnosing ALS. Early detection of ALS can improve patient survival and quality of life as well as promote…
Technology A Surgical Stent for Impermeable Anastomoses Anastomotic leak is a serious complication of gastrointestinal surgery, with consequences ranging from benign to life threatening. Treatment is costly and exposes patients to additional pain and risk. Current common…
Technology A Primary 3D Culture Model for the High Throughput Ex-vivo Modeling of Ovarian Cancer Metastasis Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between the cancer cells and the tumor…
Technology Machine Learning-Based Prediction Of Viral Mutations From Genomic Sequences There have been significant research efforts to develop machine learning and predictive analytics based tools to predict viral evolution which remains the main obstacle in the early detection of drug-resistant…
Technology Treatment Adherence Tracking For Sleep Apnea A new mobile health tool for patients with obstructive sleep apnea (OSA) using a novel CPAP adherence metric and enables tracking of lifestyle features to support behavior changes to optimize…
Technology Engineered Flt3L Variants For Antigen Tolerance Induction Engineered recombinant fusion of the dendritic cell growth factor Flt3L to serum albumin to modulate the antigen-presenting compartment and bias it toward tolerance particularly against therapeutic proteins. The Unmet Need:…
Technology Computational Framework For Unraveling Single-Cell Transcriptional Dynamics Novel system using statistical topic modeling and a bursty transcriptional model to analyze spliced and unspliced RNA, revealing precise cell state transitions and dynamics in complex biological systems The Unmet…
Technology Scalable Bioelectronic Production Of Extracellular Vesicles For Regenerative Medicine Bioelectronic devices and methods for the electrical stimulation of cells and engineered tissue for the scalable production of extracellular vesicles for drug delivery and regenerative medicine. The Unmet Need: New…
