Technology Nanoparticles Containing Multiple Cleavable Prodrugs For Cancer Therapy Specially designed nanoparticles to deliver multiple cancer drugs at once, improving drug stability, targeting tumors more effectively, and reducing side effects by controlling and triggering drug release directly at the…
Technology Synthetic Monoclonal Antibodies For Blocking Human Growth Hormone Receptor Signaling Synthetic monoclonal antibodies using phage display to bind and block the human growth hormone receptor, potentially offering a more potent and specific treatment for conditions like acromegaly by inhibiting receptor…
Technology Engineered Mutator tRNAs For Correcting Missense Genetic Defects And Inducing Cancer Cell Death Engineered tRNAs with altered anticodons and chemical modifications deliver the correct amino acid at mutated codons to restore protein function in genetic diseases or induce lethal mistranslation in cancer cells,…
Technology Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and research use. The Unmet Need: Effective…
Technology A Gene-Modified T Cell Platform For Spatially Controlled Therapeutic Protein Delivery In Response To Radiation Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for…
Technology Glycan Proximity Sequencing (GPS) For Single-Cell Multi-omics Glycoproteomics TL;DR: Glycan Proximity Sequencing (GPS) is a next-generation single-cell multi-omics assay that measures mRNA expression, extracellular protein abundance, global glycan motifs, and protein-specific glycoforms on individual cells. By combining lectin–…
Technology Topical Vitamin B1-Based Immunomodulation For Enhancing Skin Wound Healing And Anti-Tumor Responses Skincare Vitamin B1 functions as a novel immunomodulator that reprograms skin dendritic cell efferocytosis and antigen presenting cell functions, leading to enhanced skin immunity for would healing and anti-tumor purpose…
Technology Spectral CT Material Decomposition from Standard Single-Energy X-Ray Scans Summary This technology enables multi-material image reconstruction from conventional single-spectrum X-ray tomography data, including standard CT and tomosynthesis, without requiring dual-energy CT or photon-counting CT hardware. The approach can generate…
News UChicago Deep Tech Demo Day to Spotlight 22 Emerging Ventures During TechChicago Week The event will showcase next-generation deep tech ventures working across quantum and hardtech, healthcare, and data and AI.
Technology Improved Ex Vivo Models Of Pancreatic Cancer Using Tumor-Relevant Nutrient Conditions Tumor Interstitial Fluid Medium (TIFM) is a pancreatic tumor-mimetic cell culture formulation, paired with matched murine PDAC cell lines adapted in either TIFM or RPMI-1640, that is designed to model…
