Technology A Low Dose, Multi-drug Cocktail for the Treatment of Metastatic and Resistant Breast Cancers An estimated 20-30% of breast cancer patients suffer from metastatic recurrence, which can be perpetuated by an overreliance on high doses of a single drug during initial treatment. In addition…
Technology Targeting the BRCA1 Pseudogene (BRCA1P1) to Inhibit Cancer Progression and Increase Therapy Responses Compositions and methods to target long non-coding RNA (lncRNA) from the BRCA1 pseudogene in breast cancer cells to stimulate the body’s natural immune response, leading to increased cancer cell death…
Technology Engineered Cytokine-Receptor System For Enhanced Cancer And Viral Infection Treatment The technology enhances cytokine signaling and immune function, optimizing the antiviral and anti-cancer efficacy of Type III IFNs by adjusting cytokine-receptor interaction affinity and relative JAK geometry, providing an effective…
Technology Antibody-Targeted Enzymatic Chemoprotection Cytotoxic chemotherapy involves drugs that inhibit cellular division, killing or blocking the growth of cancer cells. However, chemotherapy blocks the growth of noncancerous cells, which causes an assortment of adverse…
Technology A Highly-Efficient Platform To Form Vesicular Polymer Nanoparticles For RNA And Protein Payload Delivery Polymersomes are a type of nanoscale vesicle made from block copolymers and can encapsulate a variety of therapeutic agents including proteins and nucleic acids. These nanovesicles are assembled at room…
Technology AI-Based Ultrasound Analysis System For Automated Segmentation And Classification Of Adnexal Lesions AI-driven system automatically segments adnexal masses in ultrasound images, distinguishes different tissue components, and extracts key features to accurately classify lesions as benign or malignant, improving clinical diagnosis and workflow…
Technology Antibody-Polymer Conjugates For Engaging T Cells To Destroy Cancer Cells An antibody linked to a polymer that connects T cells to cancer cells enabling broad cancer targeting and effective tumor cell killing without needing tumor-specific antigens The Unmet Need: Novel…
Technology FOXP3 Stapled Peptides to Deactivate Regulatory T Cells Regulatory T cells (Tregs) modulate immune function by preventing autoreactive T cell responses, including those that would normally target cancer cells. Treg activity can significantly limit the efficacy of immunotherapies…
Technology A Prognostic Gene Signature for Predicting Chemotherapy Sensitivity and Patient Survival in ER-negative Breast Cancer ER-negative (ER-) breast cancers make up 20% of all breast cancer diagnosis. However, no gene signature exists for predicting drug sensitivity and prognosis. Therefore, the clinical standard remains treating patients…
Technology Computational Method to Design Simultaneous Radiation Treatment of Multiple Metastatic Lesions Stereotactic ablative body radiotherapy (SART) is the precise delivery of concentrated radiation beams to a tumor from different angles. Due to the cross interaction between beams, SART is rarely able…
Technology Anti-CD73(NT5E) Antibodies Specific To The Tumor Microenvironment CD73 is an ectonucleotidase tethered by a glycosylphosphatidyl anchor to the extracellular side of many cell types. Along with NTPDase-1 CD39, CD73 is an important regulator of a cells inflammatory…
Technology Programmable Translational-Activating RNA Therapeutic Platform Technology Many human diseases arise from insufficient protein levels, often due to genetic mutations that result in haploinsufficiency or loss of protein function. Effectively treating these conditions necessitates therapeutic strategies capable…
