Technology Microbiome-Based Therapeutic For Enhancing Anti-Tumor Immunity In Cancer Treatment Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40%…
Technology Improved Ex Vivo Models Of Pancreatic Cancer Using Tumor-Relevant Nutrient Conditions Tumor Interstitial Fluid Medium (TIFM) is a pancreatic tumor-mimetic cell culture formulation, paired with matched murine PDAC cell lines adapted in either TIFM or RPMI-1640, that is designed to model…
Technology A Gene-Modified T Cell Platform For Spatially Controlled Therapeutic Protein Delivery In Response To Radiation Engineered T cells to release cancer-killing proteins only when activated by targeted radiation, enabling precise, localized tumor treatment while minimizing side effects and improving the effectiveness of CAR-T therapy for…
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
Technology A Modular LOX-Mediated Delivery Platform for Solid Tumor Immunotherapy Enhanced tumor regression and immune activation through localized retention of engineered cytokines and chemokines by lysyl oxidase-mediated crosslinking to the tumor extracellular matrix improves therapeutic efficacy while reducing systemic toxicity.…
Technology A Targeted Radiopharmaceutical Platform For Improving Diagnosis And Treatment Of Neuroendocrine Tumors Advanced imaging and targeted radiotherapy for neuroendocrine tumors, using DOTATATE-based agents for precise diagnosis and treatment, and enhancing therapy effectiveness by adding Fulvestrant as a radiosensitizer to further reduce tumor…
Technology Next-Generation Immunotherapy Platform With Engineered Collagen-Binding Cytokine Combinations Combination engineered IL-7 and IL-12 proteins that target tumors by binding to collagen, boosting immune attack on cancer while reducing side effects and improving long-term protection, even in cancers resistant…
Technology A Biomarker Analysis Platform For Predicting Immunotherapy Response And Survival In Cancer Patients A method using tumor sequencing data to measure membrane-localized neoantigens, helping predict which cancer patients will benefit from immunotherapy, even those with low tumor mutational burden, improving treatment selection and…
Page Health & Life Sciences Novel treatments, medical devices, diagnostics, and research tools spanning a range of therapeutic areas.
Technology Boosting Cancer Immunotherapy Or Radio-Immunotherapy For Enhanced Tumor Eradication New cancer therapy to enhance the efficacy of checkpoint inhibitor immunotherapy and radiation by blocking tumor-promoting signals from erythroid progenitor cells, which secrete artemin to advance cancer progression. This approach…
Technology Tumor Aneuploidy Score As A Predictor Of Immunotherapy Response Tumor aneuploidy scoring delivers improved immunotherapy response prediction, enhancing personalized cancer treatment by providing prognostic insights beyond existing biomarkers like tumor mutational burden. The Unmet Need: Reliable biomarkers to predict immunotherapy…
