Technology A Potent Glioma Targeting CAR T-Cell With Minimal Off-Target Toxicity IL13Ra2 is a cancer testis antigen that is expressed in 50-80% of glioblastoma cells, has no basal expression in the healthy tissue, and is correlated with poor patient prognosis. Problematically,…
Technology Universal TaqMan-Based Detection System for RNA Quantification Reverse transcriptase quantitative PCR (qPCR) effectively quantifies coding and noncoding RNA expressions in cells and tissue samples. Among various RT-qPCR detection systems, SYBR Green-based system is most commonly used, although…
Technology Novel Compounds for the Potentiation of Antibiotic Resistance in Staphylococcus Aureus Currently there is no available vaccine for the prophylaxis of S. Aureus mediated infections such as MRSA, and antibiotics such as beta lactams and oxacillin are most commonly used for…
Technology Silicon Nanomaterials for Neuronal Cell Activation Silicon is highly desirable for biomedical device applications because of its thermal and mechanical properties, as well as its biocompatibility. However, its practical application is presently limited by a lack…
Technology Activity-responsive Split RNA Polymerase Platform for Biosensors and Gene Therapy An understanding of protein-protein interactions (PPIs) is critical to uncovering new disease pathophysiology and for developing small molecule and antibody treatments. Problematically, current approaches to assay PPIs are limited by…
Technology Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation,…
Technology Method of Growth Factor Delivery for Accelerated Wound Healing Appearance of ulcers and slow wound healing are a hallmark symptom of several autoimmune disorders including type II diabetes. Current treatment approaches rely on antiquated bandaging, however bulkiness and inconvenience…
Technology Wide-field Super-resolution Imaging With Femtosecond Time Resolution Optical imaging techniques are limited by diffraction or acquisition time, making imaging through solid materials at the molecular level particularly challenging. As such, current spectroscopy approaches are significantly limited in…
Technology Doped Silicon Nanowires for the Selective Modulation of Single-cells Electric stimulation of organs with implantable devices has demonstrated clinical utility for the treatment of a variety of diseases such as cardiac arrythmia. However, use of these technologies remains high…
Technology Silicon Mesh for the Remote Modulation of Organ Electrical Activity Electric organ stimulation has shown promise in the clinic for treating aberrant neurological and cardiac activity. Problematically, this approach is limited by the high risk associated with surgical or gene…
Technology A Primary 3D Culture Model for the High Throughput Ex-vivo Modeling of Ovarian Cancer Metastasis Current high throughput screens for ovarian cancer drug discovery use monolayer cell culture on plastic, and problematically cannot accurately model the cross communication between the cancer cells and the tumor…
Technology Programmable And Hyperstable Engineered Synthetic Transcriptional Repressors A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as…
