Technology Conformation-Specific Genetically Encodable Intrabodies for Spatially Modulating Protein Kinase Signaling Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals, these tools enable precise, compartment-specific modulation…
Technology Type I Interferons For Enhancing Chimeric Antigen Receptor T-Cell Efficacy Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing…
Technology Computerized Adaptive Testing System For Real-Time Multidimensional Fatigability Assessment A computerized adaptive test using a bifactor model on tablet devices to measure fatigue relative to activity delivering personalized, real-time insights by integrating with electronic health records, helping clinicians make…
Technology Hydrogel Electrochemical Platform For Controlled Localized Hydrogen Delivery A portable device that generates and stores molecular hydrogen within a hydrogel using electrodes to precisely deliver hydrogen locally to treat oxidative stress in skin diseases and ischemia-reperfusion injuries The…
Technology Prolactin Receptor Antibodies For Targeted Cancer Therapy And Diagnosis Novel antibodies precisely targeting cancer cells by binding to the Prolactin Receptor (PRLR) to diagnose cancer, direct immune cells to destroy tumors, and inhibit cancer growth signals, without affecting healthy…
Technology Amphiregulin Screening And Inhibition Methods For Reducing Metastasis And Enhancing Radiotherapy Efficacy Methods to improve radiotherapy by blocking the protein Amphiregulin (AREG), which helps tumors resist treatment and spread. Inhibiting AREG enhances anti-tumor effects and reduces metastasis, making radiotherapy more effective …
Technology Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes Quantum nanoprobe system enables real-time probing of intracellular chemical environments and activity to advance biological and medical diagnostics The Unmet Need: Novel ways to probe cellular processes and improve biological…
Technology A Next-Generation mRNA Vaccine Platform For Enhancing T-Cell Responses And Improving Antiviral And Antitumor Immunity Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while…
Technology RNA Methylation Depletion To Induce Transcriptional Repression For Effective Leukemia Treatment A novel mechanism for 5-azacytidine-mediated depletion of RNA 5-methylcytosine on chromatin-associated RNA leading to global transcriptional repression through two epigenetic pathways enabling more precise and effective leukemia treatments The Unmet…
Technology Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The…
Technology Glycan Proximity Sequencing (GPS) For Single-Cell Multi-omics Glycoproteomics TL;DR: Glycan Proximity Sequencing (GPS) is a next-generation single-cell multi-omics assay that measures mRNA expression, extracellular protein abundance, global glycan motifs, and protein-specific glycoforms on individual cells. By combining lectin–…
Technology A Transcriptomic Signature Platform For Predicting Prognosis And Guiding Therapy In Ovarian Cancer Patients A 10-gene signature based on glucocorticoid receptor activity to predict survival risk in high-grade serous ovarian cancer patients, helping identify those who may benefit from specific therapies and improving personalized…
