Technology Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes Quantum nanoprobe system enables real-time probing of intracellular chemical environments and activity to advance biological and medical diagnostics The Unmet Need: Novel ways to probe cellular processes and improve biological…
Technology A Next-Generation mRNA Vaccine Platform For Enhancing T-Cell Responses And Improving Antiviral And Antitumor Immunity Next-generation mRNA vaccine platform uses a lipid-polymer hybrid nanoparticle to boost stability, immune cell uptake, and T cell responses, leading to stronger and longer-lasting protection against viruses and cancer while…
Technology RNA Methylation Depletion To Induce Transcriptional Repression For Effective Leukemia Treatment A novel mechanism for 5-azacytidine-mediated depletion of RNA 5-methylcytosine on chromatin-associated RNA leading to global transcriptional repression through two epigenetic pathways enabling more precise and effective leukemia treatments The Unmet…
Technology Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The…
Technology Glycan Proximity Sequencing (GPS) For Single-Cell Multi-omics Glycoproteomics TL;DR: Glycan Proximity Sequencing (GPS) is a next-generation single-cell multi-omics assay that measures mRNA expression, extracellular protein abundance, global glycan motifs, and protein-specific glycoforms on individual cells. By combining lectin–…
Technology A Transcriptomic Signature Platform For Predicting Prognosis And Guiding Therapy In Ovarian Cancer Patients A 10-gene signature based on glucocorticoid receptor activity to predict survival risk in high-grade serous ovarian cancer patients, helping identify those who may benefit from specific therapies and improving personalized…
Technology Antibody-Based Cell Expansion Technology For Large-Scale And Safe Amplification Of Gamma Delta T Cells Novel antibodies to rapidly and safely expand γδ T cells enabling large-scale production for cancer immunotherapies like γδ CAR-T cells, and potentially boosting these cells directly in patients The…
Technology Topical Vitamin B1-Based Immunomodulation For Enhancing Skin Wound Healing And Anti-Tumor Responses Skincare Vitamin B1 functions as a novel immunomodulator that reprograms skin dendritic cell efferocytosis and antigen presenting cell functions, leading to enhanced skin immunity for would healing and anti-tumor purpose…
Technology Rapid Selection Of High-Value Internalizing Binders For Targeted Therapeutics Lentiviral display platform engineered to directly select and enrich antibodies based on their ability to induce receptor-mediated endocytosis, thereby streamlining the discovery of highly internalizing candidates for targeted therapies The…
Technology Real-Time High-Definition Mapping Platform For Complex Cardiac Arrhythmia Intervention A novel high-resolution mapping platform offering real-time blockline angle, crossing point analytics, and fiber orientation visualization to enable targeted arrhythmia intervention and improved ablation outcomes. The Unmet Need: Current mapping…
Technology Ultrathin, Plasmonic Schottky Biointerfaces For Wireless Stimulation And Sensing A plasmon-enhanced hierarchical gold–titania (Au-TiO₂) Schottky junction biointerface designed for wireless, energy-efficient biological stimulation (neuromodulation, cardiac pacing), real-time biosensing, and minimally invasive artificial vision. The platform is scalable, CMOS-free, and…
Technology Next-Generation Minimally Invasive Optoelectronic Implants For Chronic Disease Management The platform delivers ultra-low intensity, wireless, fully implantable photostimulation for deep tissue targets (nerves, heart, diaphragm). It spatially separates light harvesting from bioelectrical stimulation, enabling minimally invasive, leadless, genetic-modification-free interventions.…
