Technology A Telescoping Catheter System for Angiography of the Left Internal Mammary Artery From a Right Transradial Approach Pedicled left internal mammary artery (LIMA) bypass grafts are performed in over 90% of coronary artery bypass graft surgeries. The grafted vasculature potentially requires future angiographic surveillance or catheterization, with…
Technology In Vitro Assay To Select Optimal Small RNA Guides To Redirect ADAR (Adenosine Deaminase That Acts On RNA) Enzymes A breakthrough method to systematically select for optimal small guide RNAs using an unbiased approach for improved accuracy and efficiency of all systems of site-directed RNA editing. The Unmet Need:…
Technology A Non-Hormonal Therapeutic Platform For Targeting M6A Regulators To Treat Uterine Fibroids A non-hormonal therapeutic strategy for uterine fibroids targeting the upregulated m6A regulator METTL3 employing small molecule inhibitors thereby reducing fibroid cell proliferation and increasing apoptosis. The Unmet Need: Novel…
Technology Small Molecule Inhibitor Boosting The Efficacy Of Therapeutic Ionizing Radiation Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is…
Technology CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for…
Technology Method for the in Vitro Generation of Trabecular Bone Trabecular (Cancellous) bone is a porous bone found in the spine and hip and is desirable for bone grafting because of its osteogenic properties. Given the difficulty of harvesting bone…
Technology Tumor-Specific Cancer Vaccine Adjuvant Formulation Many cancer vaccines fail due to insufficient CD8+ T cell targeting. To save patient lives, oncologists need tumor-specific vaccines that increase CD8+ T cell response. The inventors developed and validated…
Technology Sulfur-Containing Organic-Inorganic Hybrid Materials Organic‐inorganic hybrid sulfur‐containing materials show promising properties for a variety of applications (e.g., superconductors, thermoelectrics, etc.). Efficient synthesis of such compounds—especially those containing dithiolene‐type ligands—has historically been challenging due to…
Technology Drug Repurposing To Inhibit Nsp15 Endoribonuclease/NendU From SARS-CoV-2 There have been significant research efforts to develop various COVID-19 treatments. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus i.e. SARS-CoV-2, which has spread rapidly…
Technology Programmable And Hyperstable Engineered Synthetic Transcriptional Repressors A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as…
Technology Layered Quantum Diamond Sensors for Selective Detection and Nanoscale Spectroscopy of Biomolecules This technology is a layered device built on a diamond substrate that uses capture agents to trap specific biological or chemical targets while maintaining excellent nitrogen vacancy (NV) spin coherence…
Technology Neutralizing Monoclonal Antibodies Against SARS-CoV-2 The landscape of SARS-CoV-2 is experiencing a novel development of viral variants harboring mutations that can escape even the most highly potent antibodies against the receptor binding domain. These variants…
