Technology A Novel Class of Antibodies For The Development Of Universal Influenza Vaccines Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin…
Technology Granulobot: a modular and morphable robotic platform The development of autonomous and efficient agents that can adapt to a variety of environments and perform different functions by reconfiguring their body is one of the frontiers in the…
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
Technology DeMaND (Decoding using Manifold Neural Dynamics) This method enables high fidelity decoding of neural activity in an interpretable manner with a small training data set. The Unmet Need: Measuring neural activity in the brain with a…
Program ETA Advisory Committee Comprised of leading operators, investors, and academics in the ETA space, the Polsky Center ETA Advisory Committee is instrumental in providing guidance to the growth and impact of our ETA...
Technology Engineered Cardiac Microtissues Using Trace Silicon Nanowires To Improve Functional Maturity A trace amount of electrically conductive silicon nanowires (e-SiNWs) into otherwise scaffold-free hiPSC-derived cardiomyocyte spheroids to improve electrical coupling, synchronized beating, calcium handling, and structural maturation. The Unmet Need: Human…
Program Past Participants 2025 Folasade Rancie – Doulala Michael Gustafson – Three Pillars Sudanshu Kaushik – Exalt Data Randel Bennett – Qixent Laurel Alpaugh – Coclo Ritu Sreenivasan – Mooj Foods Shikhar Pandey…
Technology SARS-CoV-2 Monoclonal Antibodies Against Spike and Internal Proteins for Therapeutics and Diagnostics As of February 2021, there have been over 107 million cases and over 2 million deaths caused worldwide by the novel virus SARS-CoV-2. Few vaccination and treatment approaches are currently…
Technology Synergistic Combination of Immunologic Inhibitors for the Treatment of Cancer Current immunotherapy approaches often focus on targeting a single immune checkpoint or suppressive pathway, which can be insufficient given the redundancy and adaptability of tumor-mediated immune evasion. Tumors can compensate…
Technology Small Molecule Immunopotentiator Conjugates of NF-KB Activators as Adjuvants With Enhanced Efficacy And Reduced Toxicity Imidazoquinolinone derivatives that activate Toll-like receptor (TLR) 7/8 are small molecule immune potentiators (SMIPs) that have potent activity as vaccine adjuvants and as anti-tumor agents. However, these molecules have high…
