Technology Small Molecule Inhibitors Targeting RNA Modifying Enzymes to Modulate Drug Response and Overcome Drug Resistance DNA hypomethylating agents have been widely used to treat various hematologic and non-hematologic malignancies. However, accumulating evidence has demonstrated that DNA methylation status does not correlate with clinical response to…
Technology Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a reactive acid chloride intermediate that rapidly…
Technology Programmable And Hyperstable Engineered Synthetic Transcriptional Repressors A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as…
Technology Improved Electrochemical Li Extraction From Seawater And Other Dilute Li Sources Using Mixed Li An Na Layered Oxides Use of Li in electric vehicle batteries, portable electronic devices, and stationary energy storage applications has expanded significantly in recent years, and this growth is expected to continue to increase. …
Technology A Stretchable And Strain-Insensitive Pressure Sensor Pressure sensors are essential to a vast array of applications, where they sense and measure pressure, and transmit information, which help ascertain the performance of a given device. In fact,…
Technology Exploiting Chromosomal Passenger Complex (CPC) Proteins For Immunotherapeutic Applications Cell division is a fundamental biological process, ensured to be of high fidelity by the Chromosome Passenger Complex (CPC), a crucial protein complex involved in regulating various chromosomal and cytoskeletal…
Technology A Novel Class of Antibodies For The Development Of Universal Influenza Vaccines Influenza viruses remain a global health problem, with antigenically drifting seasonal viruses and the constant risk of zoonotic influenza virus spillovers into humans. Antibodies against the major surface glycoprotein hemagglutinin…
Technology Use Of Bacteriophages As Antimicrobial Agents Aagainst Klebsiella Pneumoniae Klebsiella infections are a major and growing clinical threat, particularly in hospital-acquired and device-associated settings, where multidrug resistance severely limits antibiotic options. Existing antibiotics disrupt commensal microbiota, drive resistance, and…
Technology Computational-Guided Spin Defect Systems This method enables predictive growth of qubit host materials without the limitations of iterative measurements. The Unmet Need: Proper characterization of qubit host substrate and in-situ defect growth Quantum sensors…
Technology DeMaND (Decoding using Manifold Neural Dynamics) This method enables high fidelity decoding of neural activity in an interpretable manner with a small training data set. The Unmet Need: Measuring neural activity in the brain with a…
Technology Expanding CAR T Cells Using Venetoclax For Enhanced Cytolytic Activity Against Tumors Expanding CAR T cells with venetoclax enhances their ability to target and kill CD19+ tumor cells, increases their effectiveness, and reduces exhaustion, potentially leading to better treatment outcomes for diffuse…
Technology Enhanced Nitrogen Vacancy Synthesis in Diamond: Minimizing Hydrogen Passivation Keywords: Electron radiation effects, Ion implantation, Spectroscopy, Chemical vapor deposition, Optical fibers, Quantum information This method mitigates hydrogen passivation of nitrogen vacancy centers (NV centers) in diamond through vacuum annealing…
