Technology Atomic Layer Chemical Pattern For Block Copolymer Assembly Block copolymers can assemble into large-scale, dense, and regular nanoscale patterns, making block copolymer assembly a potential candidate for nanolithography. The assembly of block copolymers can be directed to follow…
Technology A High Throughput Microfluidic Chip With Precise Environmental Control for Cell and Organoid Culture Microfluidic chips are useful in applications such as drug discovery assays because of their ability to replicate dynamic cellular environments in a high-throughput and automatable fashion. Despite this, currently available…
Technology Depalmitoylation Chemical Probes Protein palmitoylation is a post translational modification of cystine protein residues, the dysregulation of which is implicated in diseases such as Alzheimer’s, cancers, and Huntington’s. Despite the importance of palmitoylation,…
Technology Automated Microfluidic Platform For High-Throughput 3D Cell Culture, Dynamic Stimulation, And Single-Cell Analysis Automated microfluidic platform enabling high-throughput, precise 3D cell and organoid culture, drug screening, and single-cell analysis, allowing real-time monitoring and dynamic control of cellular environments for advanced research in cancer,…
Technology Library E: Highly Optimized Recombinant Antibody Phage-Display Library Using recombinant antibody libraries for drug development has numerous advantages over animal immunization including: faster production times, favorable expression, and not being limited by antigen immunogenicity. However, this approach is…
Technology Profitable Trading Strategies Devised Through Machine Learning Sentimental analysis for financial forecasting has been impeded by the ultra-high dimensional challenge of numerically representing huge troves of text. Prior efforts circumvented this bottleneck by reusing word scoring devised…
Technology Drug Repurposing To Inhibit Nsp15 Endoribonuclease/NendU From SARS-CoV-2 There have been significant research efforts to develop various COVID-19 treatments. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus i.e. SARS-CoV-2, which has spread rapidly…
Technology Machine Learning-Based Prediction Of Viral Mutations From Genomic Sequences There have been significant research efforts to develop machine learning and predictive analytics based tools to predict viral evolution which remains the main obstacle in the early detection of drug-resistant…
Technology A Biomarker Analysis Platform For Predicting Immunotherapy Response And Survival In Cancer Patients A method using tumor sequencing data to measure membrane-localized neoantigens, helping predict which cancer patients will benefit from immunotherapy, even those with low tumor mutational burden, improving treatment selection and…
Technology Model-Free Interferometry Enabled by Machine Learning Atom interferometry is used in sensors designed to measure gravitational field, acceleration, and angular momentum and is of increasing importance to the emerging field of quantum communications, which shows great…
Technology Neutralizing Monoclonal Antibodies Against SARS-CoV-2 The landscape of SARS-CoV-2 is experiencing a novel development of viral variants harboring mutations that can escape even the most highly potent antibodies against the receptor binding domain. These variants…
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
