News 21 Teams Tackling Innovations in Quantum, Healthcare, AI, and More Take First Steps Toward Commercialization Twenty-one teams from across the University of Chicago and local institutions participated in the Polsky Center I-Corps program this year – identifying and addressing real-world problems in seven weeks, work...
News How to Become a Successful CEO The following article was written by Steven Kaplan, the Neubauer Family Distinguished Service Professor of Entrepreneurship & Finance at Chicago Booth School of Business and Kessenich E.P. Faculty Director at...
Technology Nanomaterial Based Intracellular Drug Delivery Of Therapeutic Peptides Intracellular delivery involves introduction of small biomolecules, nucleic acids, proteins, synthetic nanomaterials and drugs into the cell. There is a lot of focus on targeted intracellular delivery for improved therapy…
Technology Novel Aqueous Chemical Stabilization Method for Proteins Based on the Diels-alder Reaction Stabilization of therapeutic proteins and peptides is often necessary to improve pharmacokinetic properties and reduce proteolysis in vivo. However, pre-existing stabilization strategies require expensive catalysts or harsh reagents that prevent…
Technology Diagnostic Assays And Engineered Compositions For Detecting Angiotensin II Autoantibodies And Preventing Coronavirus Autoimmunity Detection and monitoring of autoantibodies against Angiotensin II in COVID-19 patients, guiding diagnosis, treatment, and vaccine design to reduce blood pressure complications and prevent harmful autoimmune responses linked to the…
Technology Engineered Cytokine-Receptor System For Enhanced Cancer And Viral Infection Treatment The technology enhances cytokine signaling and immune function, optimizing the antiviral and anti-cancer efficacy of Type III IFNs by adjusting cytokine-receptor interaction affinity and relative JAK geometry, providing an effective…
Technology Bioorthogonal Enzyme-Probe System For Spatially Specific Biomolecule Labeling Novel proximity labeling technology utilizes a bioorthogonal protecting group, impervious to endogenous esterases, paired with evolved BS2 esterase mutants. The enzyme-mediated unmasking creates a reactive acid chloride intermediate that rapidly…
Technology Lymphangiogenesis For Therapeutic Immunomodulation A vaccine platform that uses engineered lymphangiogenesis factors and antigens to stimulate lymphatic endothelial cells, creating strong, long-lasting immune memory or tolerance with fewer side effects than traditional vaccines The…
Technology Novel Small Molecules for the Treatment of Pulmonary Fibrosis and Asthma Airway remodeling induced by asthma and fibrosis promotes reduced responsiveness to currently available therapies. As such, there is an urgent need for the development of novel treatments that target the…
Technology Hydrocarbon-Stapled Peptides To Inhibit SARS-CoV-2 Viral Infection The SARS-CoV-2 virus spreads by binding its spike protein to the human angiotensin-converting enzyme 2 (hACE2) protein expressed at the cell surface of lungs, arteries, heart, kidney, and intestines. The…
News From NVC Finalist to Global Investor, Koichiro Nakamura Continues to Support the Program That Helped Shape His Path As part of the NVC@30 celebration, Nakamura reflected on his journey from Booth student and two-time NVC finalist to Sozo Ventures cofounder, Polsky Council member, NVC judge, and longtime supporter...
