Technology RNA Editing Technology for Enhancing Tumor Immunogenicity and Immune Checkpoint Inhibitors Novel RNA editing method to generate a multitude of neoantigens in tumor cells making the cells more recognizable by T cells and enhancing the efficacy of immune checkpoint inhibitors The…
Technology Engineered Flt3L Variants For Antigen Tolerance Induction Engineered recombinant fusion of the dendritic cell growth factor Flt3L to serum albumin to modulate the antigen-presenting compartment and bias it toward tolerance particularly against therapeutic proteins. The Unmet Need:…
News ISTC Releases 2020 R&D Index and Names Three UChicago Professors Top Researchers to Know The Illinois Science and Technology Coalition (ISTC) this week released its latest R&D Index – as well as this year’s Researchers to Know, which includes three faculty members from the...
Page Where Are They Now? Episode 1 Episode 1: The Story of NVC April 15, 2021 When it launched 25 years ago, the University of Chicago’s New Venture Challenge (NVC) was a pioneer in helping business school...
News DeepTechU Day 3: Navigating Lab to Launch, Deep Tech Investment, and a Culture Shift Toward Commercialization “The best companies we see have deep venture experience,” said Beckett Jackson, investing director, Boeing HorizonX. But they also have a grand vision about how the technology will become a...
News Life Sciences Community Convenes at Chicago BioCapital Summit in a Showcase of Local Innovation Hosted by the Chicago Biomedical Consortium (CBC), the inaugural Chicago BioCapital Summit this week brought together industry, academia, and investors in a showcase of the latest innovations in the life...
Technology Next-Generation Immunotherapy Platform With Engineered Collagen-Binding Cytokine Combinations Combination engineered IL-7 and IL-12 proteins that target tumors by binding to collagen, boosting immune attack on cancer while reducing side effects and improving long-term protection, even in cancers resistant…
Technology A Highly-Efficient Platform To Form Vesicular Polymer Nanoparticles For RNA And Protein Payload Delivery Polymersomes are a type of nanoscale vesicle made from block copolymers and can encapsulate a variety of therapeutic agents including proteins and nucleic acids. These nanovesicles are assembled at room…
Technology CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for…
Technology Antibody-Polymer Conjugates For Engaging T Cells To Destroy Cancer Cells An antibody linked to a polymer that connects T cells to cancer cells enabling broad cancer targeting and effective tumor cell killing without needing tumor-specific antigens The Unmet Need: Novel…
Technology Self-assembling Nanofibril Particles for Controlled Release of IV and SUBQ Therapeutics Clinically approved methods for the controlled release of oral therapies have demonstrated their efficacy in reducing required dosage, administration frequency, and side effects, thereby boosting patient compliance. Despite these successes,…
Technology Enhanced Vaccine Efficiency via an Antigen Targeting, Immune Stimulating Co-polymer Vaccine efficacy is limited due to the inability to deliver in-tact antigens to antigen presenting (APC) dendritic cells (DCs) while simultaneously activating the cells in a non-toxic fashion. Adjuvants have…
