Technology Oral Systemically-Bioavailable Butyrate For Treating Inflammatory Diseases Method to attach butyrate to amino acids, allowing it to bypass gut metabolism and enter the bloodstream, increasing its bioavailability and enabling effective treatment of inflammatory, immune, and neurological conditions…
News 16 UChicago Researchers Awarded $7.2 Million from Chan Zuckerberg Biohub Chicago The Chan Zuckerberg Biohub Chicago has funded its first cohort of Investigators at its partner institutions – including 16 researchers from the University of Chicago. The funding – a total...
News Patent of the Week: Targeting the Treatment of Inflammatory Diseases A biologic drug delivery platform targets the treatment of inflammatory diseases by honing in on collagen exposed by inflammation. “Enhancing the therapeutic efficacy of drugs for inflammatory diseases is of...
Technology Point Of Care Monitoring Of Inflammatory Diseases A quantitative method of calprotectin measurement from various biological samples to monitor disease severity, progression, and effectiveness of treatment interventions in inflammatory diseases. The Unmet Need: A simple and quantitative…
Page Venture Gallery Venture Gallery View startups founded from across the University of Chicago ecosystem in a range of industries. Welcome to the Venture Gallery! The Polsky Center provides “first look” and early...
Technology Small Molecule Therapeutics For Inducing Trained Innate Immunity And Enhanced Anti-Tumor Responses Small molecule drugs developed to induce trained immunity in macrophage cells resulting in a heightened pro-inflammatory response without triggering a primary immune response The Unmet Need: Trained immunity induction that…
Technology CD200-Antigen Fusion Proteins For Myeloid-Targeted Antigen-Specific Immune Tolerance CD200-antigen fusion proteins target myeloid cells to deliver inhibitory CD200R signals, enhancing antigen uptake and presentation while dampening inflammation to induce antigen-specific immune tolerance The Unmet Need: Antigen-specific therapies for…
Technology Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases The Unmet Need: Safe, effective,…
Technology Novel Metabolite-Based Diagnostic Technology for Accurate Cavernous Angioma Identification and Risk Assessment Newly identified plasma metabolites linked to cavernous angioma, a neurovascular disease, using machine learning and multi-omics data to improve diagnostic precision and offer new insights for developing specific biomarkers The…
News Genes Reveal Details of ‘the Crime,’ Pathway to Develop a Novel Treatment for Neurodegenerative Disease University of Chicago researcher Christopher Gomez is developing a gene therapy to treat a rare, neurodegenerative disease – and conducting a clinical trial, backed by Pfizer and Biogen, to establish...
News Midwest Biotech Startup Showcase Spotlights 30+ Breakthrough Innovations from Leading Research Institutions Bringing breakthrough science to the forefront of innovation, the Midwest Biotech Startup Showcase will highlight more than 30 emerging life sciences and biotech ventures from leading research institutions across the...
Technology Anti-CD73(NT5E) Antibodies Specific To The Tumor Microenvironment CD73 is an ectonucleotidase tethered by a glycosylphosphatidyl anchor to the extracellular side of many cell types. Along with NTPDase-1 CD39, CD73 is an important regulator of a cells inflammatory…
