Technology Novel Nano-Formulation For Multi-TLR Agonists To Boost Immune Responses Against Solid Tumors Toll-like receptor (TLR) agonists are considered promising alternatives for the estimated 50 – 75% of all cancer patients who are non-responsive to checkpoint inhibitors, and immune activation is enhanced upon…
Technology Small Molecule Immunopotentiator Conjugates of NF-KB Activators as Adjuvants With Enhanced Efficacy And Reduced Toxicity Imidazoquinolinone derivatives that activate Toll-like receptor (TLR) 7/8 are small molecule immune potentiators (SMIPs) that have potent activity as vaccine adjuvants and as anti-tumor agents. However, these molecules have high…
Technology A New Genetic Medicine Strategy For Treating Neurological Disorders Synaptic transmission and plasticity are fundamental to neuronal functions, and alterations of synaptic protein expression are direct causes of autism, intellectual disability (ID), and epilepsy. De novo loss-of-function (LoF) mutations…
Technology Diagnostic For Predicting Hospital-Acquired Infections And Identifying Causative Organisms The technology is a fecal microbiome metabolite profile that can predict hospital-acquired infections and identify the causative organisms. This method efficiently measures specific chemical metabolites produced by bacteria in the…
Technology An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV delivery. The unmet Need: New CRISPR-systems…
Technology Small Molecule Inhibitors Targeting RNA Modifying Enzymes to Modulate Drug Response and Overcome Drug Resistance DNA hypomethylating agents have been widely used to treat various hematologic and non-hematologic malignancies. However, accumulating evidence has demonstrated that DNA methylation status does not correlate with clinical response to…
Technology Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for…
Technology Novel Compounds for the Potentiation of Antibiotic Resistance in Staphylococcus Aureus Currently there is no available vaccine for the prophylaxis of S. Aureus mediated infections such as MRSA, and antibiotics such as beta lactams and oxacillin are most commonly used for…
