Technology A Potent Glioma Targeting CAR T-Cell With Minimal Off-Target Toxicity IL13Ra2 is a cancer testis antigen that is expressed in 50-80% of glioblastoma cells, has no basal expression in the healthy tissue, and is correlated with poor patient prognosis. Problematically,…
Technology Diagnostic For Predicting Hospital-Acquired Infections And Identifying Causative Organisms The technology is a fecal microbiome metabolite profile that can predict hospital-acquired infections and identify the causative organisms. This method efficiently measures specific chemical metabolites produced by bacteria in the…
Technology Prophylactic Strategy For C. Difficile Infection Prevention This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering…
News Innovation Fund Invests $575,000 in Biotech Companies The University of Chicago Innovation Fund announced plans to invest up to $575,000 into three biotechnology companies—ImmunArtes, Onchilles Pharma, and Oxalo Therapeutics. These latest investments bring the Innovation Fund’s total...
News Polsky Accepts Record-Breaking 20 Teams for Summer Accelerator Program The Polsky Center for Entrepreneurship and Innovation has accepted 20 teams, the most ever, for its Polsky Accelerator, a 10-week intensive summer program designed for both for-profit and not-for-profit ventures....
Technology PMO-Based RNA-Degrading Chimeras For Targeted Degradation Of α-Synuclein mRNA In Neurodegenerative Diseases Phosphorodiamidate morpholino oligomer (PMO)-based RNA-degrading chimeras reduce α-synuclein protein by degrading its messenger RNA preventing protein aggregation and propagation associated with neurodegenerative diseases. The Unmet Need: More potent and selective…
Technology A Computational And Therapeutic Platform For Identifying And Correcting Unproductive Splicing To Restore Gene Expression Advanced computational tools to identify faulty RNA splicing events and design of antisense oligonucleotides to restore normal protein production in genetic diseases, especially those affecting the brain The Unmet Need:…
Technology Data-Driven Discovery Of Innate Immunomodulators Via Machine Learning-Guided High Throughput Screening Novel machine learning-enable platform to guide in vitro experimental screening and discovery of small molecule immunomodulators to improve immune responses The unmet need: Platform to resolve unregulated immune potentiator…
Technology RNA Methylation Depletion To Induce Transcriptional Repression For Effective Leukemia Treatment A novel mechanism for 5-azacytidine-mediated depletion of RNA 5-methylcytosine on chromatin-associated RNA leading to global transcriptional repression through two epigenetic pathways enabling more precise and effective leukemia treatments The Unmet…
Page Where Are They Now? Episode 4 Episode 4: Simple Mills May 6, 2021 Katlin Smith, founder and CEO of Simple Mills, wowed her first buyer with a muffin recipe using almond flour. Now the Chicago-based natural...
Page Episode Library Browse a complete collection of ETA Insider episodes from its inception in 2016. Click the episode titles below to listen, or search for “Entrepreneurship through Acquisition” on Spotify, Apple Podcasts,...
News 21 Teams Tackling Innovations in Quantum, Healthcare, AI, and More Take First Steps Toward Commercialization Twenty-one teams from across the University of Chicago and local institutions participated in the Polsky Center I-Corps program this year – identifying and addressing real-world problems in seven weeks, work...
