Page Weixin Tang // Gene Editing Tools The Tang Lab harnesses the unique properties of nucleic acid-modifying enzymes to profile, edit, and reprogram the human genome and transcriptome. This includes the discovery, characterization, and engineering of CRISPR-derived...
News 10 Teams Participate in Polsky’s Spring 2022 I-Corps Program to Refine Market Fit for Novel Tech Ten teams from across the University of Chicago were selected to participate in the spring 2022 I-Corps program with the goal of determining the commercial potential of their technologies. Supported...
Technology Context-Specific Cytosine Base Editors For Precise Single-Nucleotide DNA Editing Engineered TadA deaminase via directed evolution to produce CRISPR cytosine base editors that precisely convert target cytosines to thymines in specific DNA contexts with high efficiency and minimal off-target effects…
Technology Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase A novel platform, bacterial deaminase-enabled recoding of RNA (DECOR), utilizing an engineered bacterial adenosine deaminase to achieve programmable adenosine-to-inosine (A-to-I) editing on single-stranded RNA. The Unmet Need: Novel effector proteins…
News You Should Be Safeguarding Your Innovations The following article was written by Narayan Subramanian, PhD, senior manager, Front End of Innovation, at the Polsky Center, and originally published in Crain’s Chicago Business on August 19, 2024....
News Meet the 3 New Innovation Fellows Joining the Polsky Center This Summer The Polsky Center is welcoming three new faces this summer taking on roles as Innovation Fellows. The Polsky Innovation Fellowship features three students with technical backgrounds to support analytical and...
Page License Technologies technology Licensing Discover new solutions to expand your pipeline with breakthrough, validated technologies ready for commercialization. Technologies at the University of Chicago are available for licensing across several industries, from...
Technology Nucleic Acid Enrichment And Sequencing Method For Detecting Off-Target Base Editing Events Inrich-seq is a new method that selectively enriches and sequences inosine-containing DNA or RNA, enabling highly sensitive, genome-wide detection of off-target effects from adenine base editing in human cells The…
Technology An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity The engineered hypercompact enAsCas12f system addresses CRISPR-Cas systems deliverability issues while offering enhanced gene-editing high specificity making it ideal for therapeutic applications using AAV delivery. The unmet Need: New CRISPR-systems…
Technology Novel In Vivo Gene Editing System A engineered OgeuIscB- ωRNA for efficient and precise genome editing with increased potency and specificity while more compact in size compared to other CRISPR-Cas systems. The Unmet Need: Method to…
Technology Type I Interferons For Enhancing Chimeric Antigen Receptor T-Cell Efficacy Method to enhance CAR T-cell efficacy by incorporating low-dose exogenous IFN-α2 into CD19-directed, CD28-costimulated CAR T cells post-transduction during manufacturing boosting cytolytic molecule expression, cytokine secretion, and cytotoxicity while minimizing…
Technology Reversible Gene Editing System For Site-Specific Large DNA Integration And Excision The Unmet Need: Methods for efficient, reversible integration and excision of large DNA Genome engineering is a rapidly advancing field with immense potential for synthetic biology and gene therapy. The…
