News Polsky Center and Portal Innovations Announce New UChicago Science Incubator The Polsky Center for Entrepreneurship and Innovation has teamed up with Portal Innovations, a national venture creation and development platform, to design and manage a science startup incubator at Hyde...
News Impact in Action: Polsky Center Year in Review 2023-24 Annual Report From providing world-class entrepreneurship education to advancing the commercialization of invaluable technologies, this past year helped cement the Polsky Center’s role as the central spoke connecting...
Team Nadya Mason, PhD Vice President for Research and Robert J. Zimmer Professor of Molecular Engineering, University of Chicago Vice President for Research and Robert J. Zimmer Professor of Molecular Engineering, University of Chicago
Technology Digital Proprioceptometer For Quantitatively Assessing Human Proprioceptive Performance The Unmet Need: Precise evaluation and effective treatment planning for proprioception Proprioception is a critical aspect of human motor control and balance, traditionally evaluated during neurological and physical examinations. In…
Technology Microbiome-Based Therapeutic For Enhancing Anti-Tumor Immunity In Cancer Treatment Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40%…
Technology Boosting Cancer Immunotherapy Or Radio-Immunotherapy For Enhanced Tumor Eradication New cancer therapy to enhance the efficacy of checkpoint inhibitor immunotherapy and radiation by blocking tumor-promoting signals from erythroid progenitor cells, which secrete artemin to advance cancer progression. This approach…
Technology Small Molecule Inhibitor Boosting The Efficacy Of Therapeutic Ionizing Radiation Radiotherapy and immunotherapy are used to treat many cancer types, yet only 50% and 20% of patients respond, respectively. Resistance to therapy presents a large problem. N6-methyladenosine (m6A) modification is…
Technology Genetic Engineering Tools To Stimulate And Enhance The Production Of Select Compounds From Bacterial Species Synthetic biology toolsets to genetically manipulate the microbiota, specifically non-model resident gut microbes, to alter gene expression and cellular function to produce therapeutic compounds. Unmet Need: Genetic engineering tools for…
Technology Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases The Unmet Need: Safe, effective,…
Technology Bioadhesive Polymer for Connecting Semiconductors to Wet Tissue This method imparts bioadhesive properties onto polymeric semiconductors, which enables effective transductions of bio-signals from biological tissues to electronic devices. The Unmet Need: Conformable and stable integration of semiconductor-based biosensing…
Technology COMT inhibitors for impulsive behaviors Drug repurposing to use catechol-O-methyl-transferase inhibitors for treating impulse control disorders, obsessive-compulsive disorders, and substance addictions The Unmet Need: New options for treating impulsive behavior disorders Impulse control disorders, Obsessive-Compulsive…
Technology Pan-Specific γ9δ2 T-Cell Antibodies For Activation And Targeted Cancer Immunotherapy A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted cancer therapy. The Unmet Need: Strategy…
