Page Chuan He // RNA Modification Biology and Cancer Epigenetics Chuan He, John T. Wilson Distinguished Service Professor, Department of Chemistry, is an expert in the field of RNA modification biology and cancer epigenetics. He was the first to champion...
News UChicago’s Chuan He Recognized for Real-World Impact of Research University of Chicago researcher Chuan He has been recognized for the potential real-world impact of his work – including a method to dramatically increase crop yields and an innovative liquid...
News UChicago Spin-Out Gives Researchers a Genome-Wide View of Cell Transcription A University of Chicago spin-out company, AccuraDX is developing next-generation sequencing (NGS) technologies that enable researchers to map the location of single-stranded DNA (ssDNA) on the genome. The innovation came...
Page License Technologies technology Licensing Discover new solutions to expand your pipeline with breakthrough, validated technologies ready for commercialization. Technologies at the University of Chicago are available for licensing across several industries, from...
Technology RNA Methylation Depletion To Induce Transcriptional Repression For Effective Leukemia Treatment A novel mechanism for 5-azacytidine-mediated depletion of RNA 5-methylcytosine on chromatin-associated RNA leading to global transcriptional repression through two epigenetic pathways enabling more precise and effective leukemia treatments The Unmet…
Technology Viral RNA Modification Technique To Create Attenuated Live Vaccines For Respiratory Syncytial Virus (RSV) and Other NNS RNA Viruses A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains…
Technology Universal TaqMan-Based Detection System for RNA Quantification Reverse transcriptase quantitative PCR (qPCR) effectively quantifies coding and noncoding RNA expressions in cells and tissue samples. Among various RT-qPCR detection systems, SYBR Green-based system is most commonly used, although…
Technology OSCA: A System For Efficient Construction Of Adenovirus Vectors Adenoviruses (Ad) are a non-enveloped linear double-stranded DNA viruses with over 50 serotypes identified in humans. They have received significant attention as an in vitro and in vivo gene delivery…
Technology RNA-Guided Control Of Protein Secretion And Membrane Protein Expression Innovative methods to engineer small nucleolar RNAs to target specific mRNAs to increase or decrease the secretion of desired proteins offering scalable solutions for disease treatment and advancing research capabilities.…
Technology Low-Input Methylation Sequencing For Profiling Epitranscriptomic Signatures And Early Colorectal Cancer Diagnosis A method that analyzes cfRNA methylation in plasma to distinguish human RNA from microbiome RNA, accurately detecting colorectal cancer through specific methylation markers even in ultralow input samples. The Unmet…
Technology Spectral CT Material Decomposition from Standard Single-Energy X-Ray Scans Summary This technology enables multi-material image reconstruction from conventional single-spectrum X-ray tomography data, including standard CT and tomosynthesis, without requiring dual-energy CT or photon-counting CT hardware. The approach can generate…
News UChicago Spin-Out AccuraDX Launches KAS-seq Research Kits: ‘A New Way to Study Important Biological Processes and Regulatory Pathways’ A University of Chicago spin-out company AccuraDX this week has launched its KAS-Direct™ single-stranded DNA (ssDNA) Labeling and Enrichment Kit. Founded in 2020, the company, which is headquartered in Natick, MA...
