Technology Novel Small Molecule Treatment for Staphylococcus Aureus SSTI Infections SUMMARY Staphylococcus aureus infects 50,000 patients and kills 20,000 annually in the United States alone. With widespread antibiotic resistance, there is an urgent need for alternative mechanisms of targeting S.…
Technology Microbiome-Based Therapeutic For Enhancing Anti-Tumor Immunity In Cancer Treatment Innovative therapeutic strategy leveraging commensal microbiota, specifically by oral administration of Bifidobacterium, to enhance anti-tumor immunity, potentially improving cancer treatment when combined with checkpoint inhibitors Unmet Need: Only 20-40%…
Technology Identification of Structurally Novel BTK Mutations That Drive Resistance to BTK Inhibitors in CLL and Non-Hodgkin Lymphomas Non-Hodgkin’s lymphoma is among the most common types of cancer in the US consisting of a diverse group of lymphocytic malignancies. Most of these malignancies are B-cell of which chronic…
Technology Viral RNA Modification Technique To Create Attenuated Live Vaccines For Respiratory Syncytial Virus (RSV) and Other NNS RNA Viruses A method to attenuate RSV and other NNS RNA viruses by reducing m6A modifications on their RNA. This approach enhances genetic stability, ensures sufficient attenuation, triggers higher immune responses, retains…
Technology Small Molecule Splicing Modulators For Reducing Aggregatable Prion Protein In Prion Diseases First-in-class small molecules to change how the PRNP gene is spliced, reducing harmful prion levels and offering a new treatment approach for prion diseases The Unmet Need: Safe, effective,…
Technology Immune Modulatory Small Molecules for the Treatment of Sepsis and Autoimmune Diseases Tumor necrosis factor alpha (TNFα) is an important cytokine that activates cell death programs in response to acute inflammation. TNFα inhibitors are currently used to treat a multitude of autoimmune…
Technology Neurophysiological Biomarker for Early ALS Detection Presently, physicians rely on a costly and invasive battery of tests for diagnosing ALS. Early detection of ALS can improve patient survival and quality of life as well as promote…
Technology SCALES: A System For Predicting Interaction And Function In Bacteria Using Co-Variation The current understanding of how proteins interact to create collective functional groups (e.g., complexes, pathways, meta-pathways) is incomplete and difficult to elucidate. Therefore, the current methods used to characterize/identify the…
Technology Prophylactic Strategy For C. Difficile Infection Prevention This technology is a prevention method for those at risk of C. difficile infection using a mutated strain of C. difficile that reduces toxicity and competes with virulent strains, offering…
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
Technology Novel Delivery Platform For Controlled Release Of Bacterial Metabolites To Modulate The Immune System Conditioning of the immune system by the microbiome has received substantial attention for the scientific community in recent years. Microbial metabolites are being assessed as novel therapeutic tools for various…
Technology A Targeted Radiopharmaceutical Platform For Improving Diagnosis And Treatment Of Neuroendocrine Tumors Advanced imaging and targeted radiotherapy for neuroendocrine tumors, using DOTATATE-based agents for precise diagnosis and treatment, and enhancing therapy effectiveness by adding Fulvestrant as a radiosensitizer to further reduce tumor…
