Technology FOXP3 Stapled Peptides to Deactivate Regulatory T Cells Regulatory T cells (Tregs) modulate immune function by preventing autoreactive T cell responses, including those that would normally target cancer cells. Treg activity can significantly limit the efficacy of immunotherapies…
Technology Novel Mycobacterial Small Molecules That Bind MR1 And Are Activating Or Antagonistic For MR1-Restricted T cells. TB bacterium, Mycobacterium tuberculosis (M. tuberculosis), is extremely slow growing compared to other bacteria and is naturally resistant to many of the powerful antibiotics that are effective against other bacterial…
Technology Programmable Translational-Activating RNA Therapeutic Platform Technology Many human diseases arise from insufficient protein levels, often due to genetic mutations that result in haploinsufficiency or loss of protein function. Effectively treating these conditions necessitates therapeutic strategies capable…
Technology Neutralizing Monoclonal Antibodies Against SARS-CoV-2 The landscape of SARS-CoV-2 is experiencing a novel development of viral variants harboring mutations that can escape even the most highly potent antibodies against the receptor binding domain. These variants…
Technology Ultrasoft Hydrogel Semiconductors for High-Performance Tissue-Integrated Bioelectronic Devices This technology blends a polymer semiconductor with a hydrogel to create a tunable, biocompatible, ultrasoft network that combines efficient charge transport with tissue-like mechanical properties, which are ideal for a…
Technology Glycan Proximity Sequencing (GPS) For Single-Cell Multi-omics Glycoproteomics TL;DR: Glycan Proximity Sequencing (GPS) is a next-generation single-cell multi-omics assay that measures mRNA expression, extracellular protein abundance, global glycan motifs, and protein-specific glycoforms on individual cells. By combining lectin–…
