News AMOpportunities Launched to Help International Medical Students Secure U.S. Clinical Training Slots. Now it is Focused on Creating More Slots to Tackle a Global Physician Shortage. Dr. Romeen Lavani, chief medical officer at St. Anthony Hospital in Chicago, was skeptical when AMOpportunities first approached him about bringing international medical students to the hospital for clinical training....
News Growth of Private Equity in a Challenging Environment: the 23rd Annual Private Equity Conference Last week the Polsky Center and the Chicago Booth Private Equity Group hosted the 23rd annual Private Equity Conference, bringing investors, students, and entrepreneurs together to network and share insights...
Technology Exploiting Chromosomal Passenger Complex (CPC) Proteins For Immunotherapeutic Applications Cell division is a fundamental biological process, ensured to be of high fidelity by the Chromosome Passenger Complex (CPC), a crucial protein complex involved in regulating various chromosomal and cytoskeletal…
Technology Engineered Protein G for Creating Multivalent, Bispecific Recombinant Antibody Affinity Reagents Antibody fragments such as Fabs have demonstrated their utility as research tools, diagnostics, and in therapeutic applications. However, the monovalent nature of Fabs and lack of avidity is particularly limiting…
Technology Engineered Multipurpose Antibody Module Platform Traditionally, antibodies were produced using animal immunization methodologies. While this approach is still in broad use, recombinant display technologies have now assumed the leading role in producing antibody‐based affinity reagents. A…
Technology Anti-CD73(NT5E) Antibodies Specific To The Tumor Microenvironment CD73 is an ectonucleotidase tethered by a glycosylphosphatidyl anchor to the extracellular side of many cell types. Along with NTPDase-1 CD39, CD73 is an important regulator of a cells inflammatory…
Technology Point Of Care Technology For SARS-CoV-2 Detection and Neutralization SARS-CoV-2’s enters cells when the receptor binding domain (RBD) of its spike protein (S-protein) interacts with angiotensin-converting enzyme 2 (ACE2). In order to block this RBD-ACE2 interaction, clinicians need Point…
Technology Synthetic Monoclonal Antibodies For Blocking Human Growth Hormone Receptor Signaling Synthetic monoclonal antibodies using phage display to bind and block the human growth hormone receptor, potentially offering a more potent and specific treatment for conditions like acromegaly by inhibiting receptor…
Technology Antibody-Based Therapeutics For Inhibiting Growth Hormone Receptor Dimerization And Signaling Antibodies that block growth hormone signaling by binding the receptor or hormone to stop receptor pairing, based on high-affinity, defined sequences for therapeutic and research use. The Unmet Need: Effective…
Technology Pan-Specific γ9δ2 T-Cell Antibodies For Activation And Targeted Cancer Immunotherapy A panel of pan-specific Vγ9Vδ2 TCR-recognizing antibodies that allosterically trigger T-cell activation to engage and kill cancer cells, making it highly applicable for targeted cancer therapy. The Unmet Need: Strategy…
Technology Conformation-Specific Genetically Encodable Intrabodies for Spatially Modulating Protein Kinase Signaling Genetically encoded synthetic antibody fragments, expressed intracellularly, to specifically bind the mTOR FKBP12-Rapamycin binding domain inhibiting mTORC1 and mTORC2 activity. Fused with localization signals, these tools enable precise, compartment-specific modulation…
