Technology Programmable And Hyperstable Engineered Synthetic Transcriptional Repressors A class of functionally enhanced synthetic transcriptional factor antagonists to modulate the MYC/MAX transcriptional network by direct competition for DNA binding. The Unmet Need: Transcription factors remain largely untapped as…
Technology Point Of Care Technology For SARS-CoV-2 Detection and Neutralization SARS-CoV-2’s enters cells when the receptor binding domain (RBD) of its spike protein (S-protein) interacts with angiotensin-converting enzyme 2 (ACE2). In order to block this RBD-ACE2 interaction, clinicians need Point…
Technology Synthetic Monoclonal Antibodies For Blocking Human Growth Hormone Receptor Signaling Synthetic monoclonal antibodies using phage display to bind and block the human growth hormone receptor, potentially offering a more potent and specific treatment for conditions like acromegaly by inhibiting receptor…
Technology A Microbial Consortia That Depresses Klebsiella Pneumoniae Drug-resistant Enterobacteriaceae (particularly K. pneumoniae) are a growing cause of hospital-acquired infections, pneumonia, and antibiotic failure. Broad-spectrum antibiotics exacerbate dysbiosis and resistance, while fecal microbiota transplant lacks standardization, mechanistic clarity,…
Technology Fully Synthetic Adjuvant Delivery System For Enhanced Tumor-Targeted Immunotherapy A cancer vaccine that enhances immune response by directly binding adjuvants to tumor cells, avoiding targeting antibodies, and reducing related side effects The problem: Therapeutic vaccination has long been a…
Technology Novel RNA Replicon Vector For Efficient Gene Delivery To The Skin A Sindbis virus-based self-amplifying RNA vector has been engineered for long-lasting, safe gene expression in skin cells, aiming to treat genetic skin disorders like recessive X-linked ichthyosis by restoring missing…
Technology Nanoscale Metal-Organic Frameworks For X-Ray Triggered Combination Cancer Therapy A nanoscale metal-organic framework uses heavy metals to enhance X-ray absorption, triggering prodrug activation for precise cancer treatment by combining radiotherapy, chemotherapy, and immunotherapy with reduced systemic toxicity. The Unmet…
Technology RNA-Guided Control Of Protein Secretion And Membrane Protein Expression Innovative methods to engineer small nucleolar RNAs to target specific mRNAs to increase or decrease the secretion of desired proteins offering scalable solutions for disease treatment and advancing research capabilities.…
Technology Ultrathin, Plasmonic Schottky Biointerfaces For Wireless Stimulation And Sensing A plasmon-enhanced hierarchical gold–titania (Au-TiO₂) Schottky junction biointerface designed for wireless, energy-efficient biological stimulation (neuromodulation, cardiac pacing), real-time biosensing, and minimally invasive artificial vision. The platform is scalable, CMOS-free, and…
Technology Next-Generation Minimally Invasive Optoelectronic Implants For Chronic Disease Management The platform delivers ultra-low intensity, wireless, fully implantable photostimulation for deep tissue targets (nerves, heart, diaphragm). It spatially separates light harvesting from bioelectrical stimulation, enabling minimally invasive, leadless, genetic-modification-free interventions.…
Technology Novel RAD51 Inhibitors For Homologous Recombination Suppression And Chemosensitization A cell-active RAD51 inhibitor scaffold with an optimized reversible analog that reduces reactivity liabilities and is well suited for research-use commercialization and further oncology lead optimization The Unmet Need: Selective,…
News Enemsa Pharma Secures Rights from UChicago to Develop Novel Therapeutic Enemsa Pharma has been granted exclusive patent rights from the University of Chicago to use a family of small molecules for the treatment of demyelinating diseases.
