News Startup Spotlight: Debate It Forward The Polsky Center spoke with founder Josh Aaronson about his time in the Summer Accelerator and College New Venture Challenge programs.
News Drug Delivery, Diagnostics, AI Applications Among 10 Projects in the Spring 2021 I-Corps Cohort Ten teams are participating in the spring 2021 cohort of the Polsky I-Corps program – a highly experiential, 7-week-long program to empower scientists, researchers, and students to test the commercial...
News Senator Klobuchar to Moderate ‘Kid Presidential Debate’ with UChicago Startup Debate It Forward Debate It Forward (DIF), an education non-profit promoting healthy discourse in youth, this week is hosting its own “Kid Presidential Debate” moderated by former presidential candidate and University of Chicago...
Technology A Method for Fast Adapting Similarity Searches Based on Variance Aware Quantization With the explosive growth of high-dimensional data, approximate methods emerge as promising solutions for searching for similar data pairs. Quantization methods have gained prominence due to their low storage costs…
Technology New Platform For Targeted Immunomodulation And Vaccine Development There have been significant research efforts to develop effective vaccines that elicit a strong and durable T cell response against intracellular pathogens and cancer. A popular strategy has been to…
Technology Nanovaccine That Activates The NLRP3 Inflammasome & Enhances Tumor Specific Activation Of Anti-Cancer Immunity A major attention of vaccine adjuvant development has been focused on development of robust antibody-mediated protection against pathogens. However, such adjuvants have failed to elicit a robust T-cell mediated protection…
Technology Data-Driven Discovery Of Innate Immunomodulators Via Machine Learning-Guided High Throughput Screening Novel machine learning-enable platform to guide in vitro experimental screening and discovery of small molecule immunomodulators to improve immune responses The unmet need: Platform to resolve unregulated immune potentiator…
Technology Novel Nano-Formulation For Multi-TLR Agonists To Boost Immune Responses Against Solid Tumors Toll-like receptor (TLR) agonists are considered promising alternatives for the estimated 50 – 75% of all cancer patients who are non-responsive to checkpoint inhibitors, and immune activation is enhanced upon…
Technology Small Molecule Immunopotentiator Conjugates of NF-KB Activators as Adjuvants With Enhanced Efficacy And Reduced Toxicity Imidazoquinolinone derivatives that activate Toll-like receptor (TLR) 7/8 are small molecule immune potentiators (SMIPs) that have potent activity as vaccine adjuvants and as anti-tumor agents. However, these molecules have high…
Technology Small Molecule Therapeutics For Inducing Trained Innate Immunity And Enhanced Anti-Tumor Responses Small molecule drugs developed to induce trained immunity in macrophage cells resulting in a heightened pro-inflammatory response without triggering a primary immune response The Unmet Need: Trained immunity induction that…
Technology Tolerizing Agonist/Immunomodulator Loaded Liposomes for Long-Lived Immune Tolerance A failure of central immune tolerance typically driven by autoantigen specific T regulatory (Treg) cells is the primary cause of many autoimmune diseases. This technology generates antigen specific immune tolerance…
Technology Engineered Flt3L Variants For Antigen Tolerance Induction Engineered recombinant fusion of the dendritic cell growth factor Flt3L to serum albumin to modulate the antigen-presenting compartment and bias it toward tolerance particularly against therapeutic proteins. The Unmet Need:…
